A multitude of genes have been linked to the development of Alzheimer's disease. Specifically how those genes might influence the progression of neurodegeneration remains something of a black box ...

Scientists at the Institute for Basic Science (IBS) have uncovered a non-invasive method to boost the brain's natural waste drainage system—a discovery that could open new avenues for tackling ...

Brain-derived extracellular vesicle (EV) biomarkers represent a promising frontier for liquid biopsy development targeting the nervous system. They offer strong potential for enabling minimally ...

The rapid influx of cerebral spinal fluid (CSF) and protein solutes released during cortical spreading depression (CSD) in the brain activates neurons to trigger aural migraine headaches, according to ...

Specialized brain cells in the hypothalamus act as a disposal route for tau protein, shuttling it from cerebrospinal fluid into the bloodstream. When those cells break down, tau accumulates in the ...

Biofluid proteomics revealed distinct inflammatory signatures in Alzheimer’s patients with fast vs slow tau progression. While plasma and CSF showed different proteins, both pointed to shared ...